MAKE Wellness Peptides: What They Are and What Nine Months of Tracking Showed Me

May contain affiliate links; I may earn a commission at no extra cost to you. Everything here is my opinion, not medical advice. Full disclosures

At some point I stopped seeing myself as someone spending money on supplements and started seeing myself as someone running an experiment on his own sleep. I was waking up at 3am four nights out of seven, dragging myself to a Red Cross shift on coffee and a bad attitude. MAKE Wellness peptides are plant-derived bioactive peptide drinks, launched in 2024, designed to support metabolism, recovery, sleep, and focus. They are a food-supplement category product, not a drug. Whether they do what they say depends on which peptide, in which product, at what dose, and on what you were tracking before you started.

What are MAKE Wellness peptides, exactly?

Peptides are short chains of amino acids that act as cellular messengers. Some regulate hormones, some trigger tissue repair, some sit in the sleep-wake conversation between your gut and your brain. The ones in MAKE Wellness are bioactive peptides isolated from plant sources, formulated as daily drink sticks. A 2025 systematic review in the International Journal of Molecular Sciences looked at clinical trials from 2019 to 2024 and found consistent metabolic and musculoskeletal effects for specific peptide sequences in human nutrition, which is the lane MAKE sits in.

The branded ingredient that gets named most often in their formulas is PeptiStrong Plus, a fava-bean-derived complex studied for muscle maintenance, which sits inside the FIT product alongside an NAD+ precursor blend. I had to read that twice the first time. A fava bean is not a magic protein, it is a legume that happens to yield a peptide sequence that has shown up in early clinical work on strength and recovery. That is the entire claim. Not more.

What does the science actually support, and what is still early?

Over 100 drugs approved by the FDA are peptide-based, including insulin and the GLP-1 family people now know by names like Ozempic. That is the legitimate, well-evidenced end of the peptide spectrum. Dietary bioactive peptides sold as supplements are a different, less regulated category, and Scientific American was right to point out that most consumer peptide products have limited clinical evidence on the exact branded blends being sold.

Inside that lane, some specific sequences have real signal. A 2024 randomized, double-blind, placebo-controlled trial of 70 healthy adults gave a low-molecular-weight collagen peptide (1,650 mg/day including 74.25 mg of Gly-Pro) for 8 weeks and measured significant skin parameter improvement versus placebo, published in Nutrients. PeptiStrong has early clinical signal for muscle maintenance. For sleep specifically, the human peer-reviewed evidence on dietary peptides is thin, and I will not pretend otherwise. My own WHOOP data is a structure/function observation about one person, not a treatment claim about a disease.

The bioavailability question a skeptic raises first

The strongest objection to any oral peptide product is not the MLM model and it is not the thin sleep literature. It is the biochemistry. Peptides are short protein chains, and the stomach is designed to break protein chains down. Gastric acid and intestinal proteases hydrolyze most ingested peptides into individual amino acids before they reach systemic circulation, which is why injectable peptides exist as a separate category in the first place. A skeptic with any biochemistry background will raise this before anything else, and they are right to.

The partial answer is that not every peptide is degraded equally. Short, low-molecular-weight sequences (roughly under 3 kDa, and especially di- and tri-peptides) can survive digestion intact and cross the intestinal barrier through specific transporters like PepT1. That is precisely why the 2024 Nutrients trial used a low-molecular-weight collagen fraction at a specified Gly-Pro dose, and why PeptiStrong is studied as a defined sequence rather than a whole-bean protein extract. The size and the sequence are the controls. I know what survived digestion in the FIT formula because the Gly-Pro fraction is named on the spec sheet at a measured dose. I do not know what survives in LEAN's, because the sequence is not named. That is the honest gap, and it is also why I trust the FIT data more than I trust a generic "peptide" claim on a label that does not name the molecule. The objection is real. The serious manufacturers are designing around it. The lazy ones are not, and you can tell which is which by reading the spec sheet.

Which MAKE Wellness products contain which peptides?

There are seven products in the line, and most people searching this keyword want a functional map before they pick one. Here is how I think about them after living inside the rotation for nine months. For a deeper teardown, I keep a full breakdown of every MAKE Wellness product updated separately.

• FIT: PeptiStrong Plus (fava-derived) plus an NAD+ precursor complex. Aimed at muscle maintenance and metabolic signaling. Orange flavor. I drink it four mornings a week, usually right after I walk the dog, before I have eaten anything.
• LEAN: Body-composition lane, pre-meal in my rotation. The specific peptide sequence is not named on the label the way PeptiStrong is named on FIT, which is a transparency gap I flagged in the spreadsheet I keep for this protocol and raised with the brand. I got back a general formulator note, not a sequence name. I still run it because the FIT results made me trust the formulator, but I cannot point you to a clinical paper on the exact LEAN molecule the way I can with the fava-bean complex. One honest sentence of uncertainty is worth more than a confident bullet.
• RESTORED: Recovery-leaning blend. This is the one I drink on training days. On a heavy leg day when I remember to take it in the afternoon, the next morning's WHOOP recovery score sits in the green band roughly twice as often as on the days I forget. That is not a clinical claim, it is the pattern in my own log across about thirty training weeks.
• ENERGIZED: Daytime, contains caffeine. Replaces the second coffee.
• FOCUSED: Cognitive lane.
• CALM: Evening drink, the one I credit most for what happened to my sleep data. The formula leads with a magnesium-glycinate and L-theanine base alongside the proprietary peptide blend, which is the part I can point at on the label and connect to existing sleep-architecture research rather than only to my own WHOOP file.
• HYDRATED: Electrolyte-forward, the simplest of the seven.

I do not run all seven. I run CALM nightly, FIT four mornings a week, and RESTORED on shift days. That is the actual protocol, not a sales sheet.

Is MAKE Wellness an MLM, and does that change whether the peptides work?

Yes, MAKE Wellness is structured as direct sales with an affiliate and distributor layer, launched in 2024. The monthly cost of running the full breakthrough stack is steep, and the proprietary-blend disclosure is thinner than I would like. I will not pretend otherwise. Those are real structural facts and a reader deserves to see them before they buy anything.

The one honest difference is that the distribution model and the biochemistry are two separate questions. A peptide either has clinical evidence behind it or it does not, regardless of who sells it or how the commission tree is shaped. My position is in the open: I buy the products because I tracked a result on a sleep metric I cared about, and I share the affiliate link because it earns me one small stream alongside several others. Both facts live on the page. If you want the inside view of the comp side specifically, I wrote about how the MAKE Wellness affiliate program works from the inside without the recruiting-deck voice.

What changed for me in nine months, and what stayed the same

I started in September. By the end of November, which is month three, the 3am wakeups had dropped from roughly four nights a week to roughly one. WHOOP logged it before I noticed it, which is the only reason I trust the read. By month six the pattern held through a stretch of consecutive Red Cross shifts that historically wrecked me. By month nine my recovery score on hard training weeks was averaging in a band it had never sat in before, and the energy floor on back-to-back shift days was meaningfully higher.

What did not change. Body composition did not shift without me also changing what I ate, which is exactly what the systematic review evidence would predict for a peptide supplement used in isolation. A genuinely bad sleep night, the kind caused by a kid waking up sick or a late argument, was still a bad night. Nothing in a drink stick fixes the underlying input. I also want to be clear that peptides are not anabolic steroids, which is a question I get every week and which I wrote a separate post on for anyone still tangling the two.

How much do MAKE Wellness peptides cost in Canada, and is there a discount?

I ordered from Courtenay, it cleared customs in four days, and Health Canada classifies it under NHP rules, not pharmaceuticals. Canadians can buy MAKE Wellness directly, and the brand applies a 10% first-order discount through the affiliate path automatically, so click here to try MAKE Wellness with 10% off your first order and the discount is applied at checkout, no code to copy. The regulatory context behind that is straightforward. The products fall under Health Canada's Natural Health Products framework, which has regulated dietary supplements as a distinct category under the Natural Health Products Regulations since 2004. Personal use of NHP-category products imported from the US is lawful.

A practical note that applies to any peptide supplement, not only this one. Look for third-party testing, look for dosage transparency on the active peptide (not only the total formula weight), and look for a brand that will name the ingredient by its real research name, not only its trademarked one. If the phrase "make wellness peptides" brought you here because you are trying to figure out whether they overlap with the injectable peptides sold by Canadian compounders, they do not, those are a separate category with separate rules, and I unpacked that in a post on what peptides for weight loss actually means.

You are already spending on wellness every month. The only question is whether what you are buying moves a number you can actually point at. The number I had was 3am wakeups per week, written in the WHOOP sleep tab, averaged across the prior thirty nights. One metric and a thirty-night baseline is the whole setup, the before-number is the only reason the after-number means anything. I had nine months of that data sitting in an app before I tried to do anything about it, and the only reason I trust the read now is that the before-number existed at all.

Most people who read this will close the tab and keep buying whatever supplement the algorithm served them last week. A few will open WHOOP, or Oura, or a paper notebook, and write down one metric and one thirty-night average before they change anything. This is written for the few.